Legalon is a herbal preparation, the active substance in it is a dry extract of milk thistle fruit. Silymarin, which is part of the milk thistle fruit extract – is a plant antioxidant complex that has a healing effect on the liver. Milk thistle contains many biologically active substances, including several types of silymarin and the silymarin isomer silibinin, which have a hepatoprotective effect.
The effect of silymarin and its isomers is based on their antioxidant properties. They inhibit the peroxidation of lipids, which prevents the destruction of the membranes (membranes) of hepatocytes. Silymarin promotes the recovery of hepatocytes by activating the action of intracellular enzymes. It stimulates the intracellular formation of proteins and phospholipids, which are the main components of cell membranes. Strengthening of the membranes contributes to the preservation and rapid recovery of hepatocytes.
Silymarin prevents some hepatotoxic poisons from entering the hepatocytes, for example, the venom of the pale toadstool mushroom. In addition, silymarin suppresses the formation of prostaglandins — the main components of the inflammatory process, that is, it has an anti-inflammatory effect.
The restoration of cellular metabolism is promoted by tocopherols, minerals (potassium, magnesium, copper, selenium), unsaturated fatty acids contained in milk thistle fruits. The latter actively contribute to the oxidation of cholesterol, which prevents the spread of atherosclerosis.
Biologically active substances of milk thistle fruits also have a positive effect on the gastrointestinal tract, the processes of digestion and the formation of bile.
After a course of treatment with Legalon, patients with liver diseases improve their general condition, including they are less concerned about weakness, pain in the right hypochondrium, vomiting, itching, loss of appetite, etc.At the same time, laboratory indicators that indicate the state of liver function improve.
It is impossible to fully establish the process of promoting Legalon in the human body, since it contains too many biologically active substances. But it was found that after taking Legalon inside, its concentration in the blood plasma reaches a maximum in half an hour.
The main part of the drug is excreted with bile in the form of metabolic products. Maximum excretion with bile is achieved after 2 hours. As a result of interaction with the intestinal microflora, almost half of the silymarin released with bile is reabsorbed in the intestine, forming the intestinal-liver cycle.
Capsules and dragees are taken orally, swallowed whole, washed down with water. Taking Legalon is not associated with eating. The dosage of the drug, the frequency of its administration during the day, the duration of the course of treatment is determined by the attending physician, depending on the condition and age of the patient.
Instructions for use Legalon 140: the drug is taken 1 capsule twice or three times a day. With a long course of treatment, the drug is enough to take twice a day.
The standard course of treatment is at least 12 weeks, but it can last several months.
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