Essential phospholipids are the main elements of the structure of the cell membrane and cell organelles. In liver diseases, there is always damage to the membranes of the liver cells and their organelles, which leads to disruptions in the activity of enzymes and receptor systems associated with them, impairment of the functional activity of liver cells and a decrease in the ability to regenerate.
The phospholipids that make up Essentiale® forte N correspond in their chemical structure to endogenous phospholipids, but surpass endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids. The incorporation of these high-energy molecules into the damaged areas of the cell membranes of hepatocytes restores the integrity of the hepatic cells and promotes their regeneration. The cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the phospholipids of the cell membranes, the phospholipid structure of the cell walls of hepatocytes “loosens”, which leads to an increase in their fluidity and elasticity, and improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on the membranes and contribute to the normal, physiological pathway of the most important metabolic processes.
Phospholipids, which are part of Essentiale® forte, regulate lipoprotein metabolism, transferring neutral fats and cholesterol to the sites of oxidation, mainly by increasing the ability of high density lipoproteins to bind to cholesterol.
Thus, there is a normalizing effect on the metabolism of lipids and proteins; on the detoxification function of the liver; to restore and preserve the cellular structure of the liver and phospholipid-dependent enzyme systems; which ultimately prevents the formation of connective tissue in the liver and promotes natural regeneration of liver cells.
When phospholipids are excreted into bile, the lithogenic index decreases and bile stabilizes.
In patients with non-alcoholic fatty liver disease, the use of essential phospholipids in controlled randomized clinical trials led to a significant decrease in the degree of steatosis.
In clinical and observational studies against the background of the use of Essentiale® Forte N in patients with chronic liver diseases, relief of the general condition and symptoms, such as increased fatigue / weakness, decreased appetite, pain or discomfort in the abdomen, a feeling of rapid satiety, a feeling of fullness or heaviness after eating, bloating, nausea. Significant improvement in symptoms was noted in studies as early as 4 weeks (30 days) of therapy.
The use of essential phospholipids in controlled and observational studies in patients with psoriasis led to regression of psoriatic eruptions, a decrease in the prevalence index and severity of psoriasis (PASI). The addition of essential phospholipids to PUVA therapy made it possible to achieve faster remission while reducing the total dose of ultraviolet radiation.
Application methods
Inside.
The capsules should be swallowed whole with plenty of water (about 1 glass).
For adolescents over 12 years of age and weighing more than 43 kg, as well as for adults Essentiale® Forte N, it is recommended to take 2 capsules – 3 times a day with meals.
The recommended course of therapy is 3 months.
The course can be individually determined by the doctor.
Composition
1 capsule contains:
active ingredient: phospholipids from soybeans, containing 76% (3-sn-phosphatidyl) -choline (synonyms: EPL, essential phospholipids) – 300 mg;
auxiliary ingredients: solid fat – 57,000 mg, soybean oil – 36,000 mg, hydrogenated castor oil – 1,600 mg, ethanol 96% – 8,100 mg, ethyl vanillin – 1,500 mg, 4-methoxyacetophenone – 0.800 mg, α-tocopherol – 0.750 mg.
Composition of the capsule: gelatin – 67.945 mg, purified water – 11.495 mg, titanium dioxide (E 171) – 0.830 mg, iron dye yellow oxide (E 172) – 2.075 mg, iron dye black oxide (E 172) – 0.332 mg, iron dye red oxide (E 172) – 0.198 mg, sodium lauryl sulfate – 0.125 mg.
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